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Cissus Quadrangularis

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Product Options: Capsules - 60 x 500 mg
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Cissus Quadrangularis is an all-natural herbal supplement that functions as a potent and powerful weight loss supplement, helps regulate blood sugar levels, provides anti-inflammatory properties, and is also naturally rich in antioxidants making it great for overall general health. Read the full product description for more information.


What is Cissus Quadrangularis?

Cissus Quadrangularis is an all-natural herbal supplement that has been used for medicinal purposes for hundreds upon hundreds of years, particularly in Indian medicine. It is actually a vine found in Asia and parts of Africa, and provides countless medicinal benefits for the human body. It is a member of the grape family, and is even sometimes known as devil’s backbone, or veldt grape. As this vine has been found to be so healthy and beneficial, Cissus Quadrangularis is now available in supplement form, and is proving to be very popular. It is renowned for its ability to help bones and injuries to heal quicker, plus it can assist with weight loss, and can help regulate blood sugar levels.

How does it work?

Cissus works in a number of ways, depending on what you’re using the supplement for. As mentioned, as it functions as a potent and powerful weight loss supplement, it functions by helping to suppress the appetite, helping to keep us feeling full for longer, and helping us to consume less calories than normal. This is because it is rich in HCA, which helps to inhibit ATP citrate lyase, which is an enzyme that helps to convert carbohydrates into fat. As the enzyme is blocked, this in turn helps to prevent carbohydrates being converted into body fat. It is also why Cissus is considered so beneficial for helping to regulate blood sugar levels. In terms of joint health, Cissus is beneficial as it provides anti-inflammatory properties which can help reduce inflammation on and around the joints, making it great for arthritis. It is also naturally rich in antioxidants and other nutrients that boost the immune system, making it great for general health and well-being.

What are the main benefits of Cissus Quadrangularis?

Some of the primary benefits associated with this supplement include:

Weight loss

As mentioned, due to the fact that it helps to prevent carbohydrates from being stored as body fat, plus the fact that it suppresses the appetite, Cissus Quadrangularis has been found to be a very healthy and very beneficial weight loss supplement. The carbs are used as energy instead of being stored as body fat, and as you feel full quicker and have less appetite, you will consume less calories.

Increased energy levels

Another fabulous benefit of this supplement, is the fact that it has been found to naturally increase your energy levels, which again, is mainly down to the fact that it encourages the body to utilize carbohydrates as energy right away, instead of breaking them down and converting them into body fat.

Strengthened immune system

The supplement is also packed full of vitamins, minerals, antioxidants, and other nutrients that have been found to greatly strengthen and enhance the immune system. In terms of general health and well-being, Cissus really comes into its own.

Other benefits include:

  • Improved joint health
  • Suppressed appetite
  • More energy
  • Strengthened immune system
  • Fat loss
  • Healthy joints
  • Healthy bones
  • Regulated blood sugar levels
  • Reduced inflammation in the body and joints
  • And more...

How and when should it be consumed

Health Canada Recommended Dose (capsules): Adults: 1 Capsule(s) 1 - 2 time(s) per day.

Glucosamine VS Cissus Quadrangularis

Cissus Quadrangularis is a supplement that provides a number of benefits for the body, including for being able to help reduce joint pain and inflammation. Glucosamine is often compared with the supplement, as it too is great for the joints. Despite this however, the two do have their differences. Glucosamine for example, provides connective tissue substrate, whereas Cissus has been found to help speed up calcification in bones, especially following an injury. Then of course, there are the many non-bone and joint benefits associated with Cissus, although many people actually stack the two together, as you’ll see in just a moment.

What can you stack it with?

As mentioned, Cissus is often stacked with other joint health supplements including: Glucosamine, Omega 3, 6, 9, and MSM. In terms of general health and well-being however, Cissus Quadrangularis can be stacked with multivitamin, and minerals such as zinc and iron.

Cissus Quadrangularis Ingredients

Ingredients Per Capsule

Medicinal Ingredients (per capsule):
Veldt-grape (Cissus quadrangularis, Stem) ............................................... 500 mg
Hyaluronic acid (Hyaluronic acid, Gallus gallus - Comb) ............................ 50 mg
Non-Medicinal Ingredients: Gelatin.

Potential side effects

As always, always make sure you consult your doctor before using any new supplements, and that you discontinue usage if you experience any negative side effects. Pregnant and breastfeeding women should not take Cissus as not enough is known about its safety. As it helps to regulate and lower blood sugar levels, diabetics may need to be careful as insulin or medicine such as metformin, which also lowers blood sugar levels, could potentially reduce blood sugar levels by too much. Other potential side effects include:

  • Intestinal gas
  • Slight headache
  • Dry mouth
  • Restlessness
  • Slight stomach cramps


Caution: Not intended for children, pregnant, or breastfeeding women. Consult a healthcare practitioner prior to use. Consult a healthcare practitioner prior to use if you have health conditions. Store in a cool dry place away from children. Do not use if seal is broken.

Allergen warnings

Allergy Statement: This product is made in a facility that handles milk products, gluten, shellfish, soy, peanuts and other tree nuts.

Disclaimer: The above description does not constitute medical advice and is for informational purposes only and has not been evaluated by Health Canada, CFIA, or FDA. Please consult a properly licensed medical professional before consuming nutritional supplements. This product is not intended to treat, diagnose or cure any disease.

Customer Reviews

Based on 26 reviews
Alexandra Barberena
So far so good

Bruising healed up quicker than before

Connel Robinson

Cissus Quadrangularis

Ron Baksh
No Sissy Cissus

Cissus seems to do the things that it purports to do. Specifically, reduces inflammation, hastens sleep and improves sleep depth, and aids in workout recovery.

Kwonhee An

Cissus Quadrangularis

Chrisoula Kodopulos
Very effective

After 2 weeks of taking this product, my osteoarthritis in my knees has subsided substantially . I'm very pleased